MCAT Biology : Molecular Properties

Study concepts, example questions & explanations for MCAT Biology

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Example Questions

Example Question #4 :Other Properties Of Biological Compounds

Which compound does not have any atoms with bond angles of?

Possible Answers:

Correct answer:

Explanation:

By drawing the Lewis structures of these molecules, we can determine the bond angles between the atoms. The following molecular geometries contain bond angles of: octahedral, trigonal bipyramidal, and square planar.

has a tetrahedral geometry, which means that there are only bond angles of.

will be square planar.will be octahedral.will be trigonal bipyramidal.

Example Question #5 :Other Properties Of Biological Compounds

Which of the following compounds is the most stable?

Possible Answers:

2,4-cyclobutadiene

Cyclohexane

1,3-dichlorocyclooctane

Benzene

Cyclopentane

Correct answer:

Benzene

Explanation:

Aromatic compounds are highly stable due to resonance stability. The two aromatic choices are benzene and 2,4-cyclobutadiene. Because a six-carbon ring is more stable than a four-carbon ring, benzene is the best answer. Ring strain will distort a four-carbon ring, increasing its bond energy and decreasing its stability.

Example Question #6 :Other Properties Of Biological Compounds

Which of the following statements is not true concerning resonance structures?

Possible Answers:

Resonance atoms are in the same plane

There is a constant number of unpaired electrons

The number of double bonds is constant between structures

Atoms do not move between structures

Correct answer:

The number of double bonds is constant between structures

Explanation:

There is no requirement that the number of double bonds in a molecule be kept constant. Electrons can be moved in order to convert between triple bonds, double bonds, and single bonds when transitioning between resonance structures.

Example Question #7 :Other Properties Of Biological Compounds

Nuclear transport is a very important concept of study in modern cellular biology. Transport of proteins into the nucleus of an organism requires energy in the form of GTP, which is attached to a protein called Ras-related Nuclear protein (RAN).

RAN is a monomeric G protein found in both the cytosol as well as the nucleus and its phosphorylation state plays an important role in the movement of proteins into and out of the nucleus. Specifically, RAN-GTP and RAN-GDP binds to nuclear import and export receptors and carries them into or out of the nucleus. They also play a role in dropping off cargo that import and export receptors hold onto. RAN's functions are controlled by two other proteins: RAN guanine exchange factor (RAN-GEF) and RAN GTPase activating protein (GAP). RAN-GEF binds a GTP onto RAN, while RAN-GAP hydrolyzes GTP into GDP. As a result, there is a RAN-GTP and RAN-GDP concentration gradient that forms between the cytosol and nucleus.

Suppose an experiment was done and the concentrations of RAN-GEF and RAN-GAP were determined, as shown below:

Nucleus:

Cytosol:

Given these results, what can be said about the charge of RAN in the cytosol and nucleus?

Possible Answers:

RAN is more positively charged in the cytosol than in the nucleus

RAN has equal charge in both the nucleus and cytosol

RAN is more positively charged in the nucleus than in the cytosol

RAN's charge may fluctuate depending on the metabolic state of the cell

RAN's charge state cannot be determined without further experimentation

Correct answer:

RAN is more positively charged in the cytosol than in the nucleus

Explanation:

First, we have to understand which of the proteins exist in higher concentrations and the impact of both proteins. From the information, we can see that RAN-GEF has a higher concentration in the nucleus than in the cytosol, and that RAN-GAP has a higher concentration in the cytosol than in the nucleus. RAN-GEF will add on a GTP group onto RAN, whereas RAN-GAP will hydrolyze the RAN-GTP to RAN-GDP.

We can therefore conclude that RAN-GTP exists at a higher concentration in the nucleus, and that RAN-GDP exists at a higher concentration in the cytosol. Since GTP has a more negative charge than GDP, RAN will have a more negative charge in the nucleus, or conversely that RAN will have a more positive charge in the cytosol.

Example Question #8 :Other Properties Of Biological Compounds

The central nervous system consists of the brain and the spinal cord. In general, tracts allow for the brain to communicate up and down with the spinal cord. The commissures allow for the two hemispheres of the brain to communicate with each other. One of the most important commissures is the corpus callosum. The association fibers allow for the anterior regions of the brain to communicate with the posterior regions. One of the evolved routes from the spinal cord to the brain is via the dorsal column pathway. This route allows for fine touch, vibration, proprioception and 2 points discrimination. This pathway is much faster than the pain route. From the lower limbs, the signal ascends to the brain via a region called the gracile fasciculus. From the upper limbs, the signal ascends via the cuneate fasciculus region in the spinal cord.

One of the most common neurotransmitters is acetylcholine. Which of the following statements is/are true?

I. The neurotransmitter is water soluble

II. The neurotransmitter is lipid soluble

III. The neurotransmitter has a charge

Possible Answers:

None of these

二只

III only

I only

I and III

Correct answer:

I and III

Explanation:

Acetylcholine is water soluble, which is in opposition to claim II. Furthermore, most water soluble molecules have some degree of charge polarity. Acetylcholine does indeed have a charged amino group, which contributes to its polarity and solubility in water.

Example Question #9 :Other Properties Of Biological Compounds

The cellular membrane is a very important structure. The lipid bilayer is both hydrophilic and hydrophobic. The hydrophilic layer faces the extracellular fluid and the cytosol of the cell. The hydrophobic portion of the lipid bilayer stays in between the hydrophobic regions like a sandwich. This bilayer separation allows for communication, protection, and homeostasis.

One of the most utilized signaling transduction pathways is the G protein-coupled receptor pathway. The hydrophobic and hydrophilic properties of the cellular membrane allows for the peptide and other hydrophilic hormones to bind to the receptor on the cellular surface but to not enter the cell. This regulation allows for activation despite the hormone’s short half-life. On the other hand, hydrophobic hormones must have longer half-lives to allow for these ligands to cross the lipid bilayer, travel through the cell’s cytosol and eventually reach the nucleus.

Cholesterol allows the lipid bilayer to maintain its fluidity despite the fluctuation in the body’s temperature due to events such as increasing metabolism. Cholesterol binds to the hydrophobic tails of the lipid bilayer. When the temperature is low, the cholesterol molecules prevent the hydrophobic tails from compacting and solidifying. When the temperature is high, the hydrophobic tails will be excited and will move excessively. This excess movement will bring instability to the bilayer. Cholesterol will prevent excessive movement.

Which of the following hormones utilizes cholesterol as its precursor?

I. Cortisol

II. Testosterone

III. Dihydroxytestosterone

Possible Answers:

None of these

I, II and III

III only

I only

二只

Correct answer:

I, II and III

Explanation:

Cortisol and testosterone both utilizes cholesterol to the precursor. Dihydrotestosterone is a potent form of testosterone.

Example Question #10 :Other Properties Of Biological Compounds

The cellular membrane is a very important structure. The lipid bilayer is both hydrophilic and hydrophobic. The hydrophilic layer faces the extracellular fluid and the cytosol of the cell. The hydrophobic portion of the lipid bilayer stays in between the hydrophobic regions like a sandwich. This bilayer separation allows for communication, protection, and homeostasis.

One of the most utilized signaling transduction pathways is the G protein-coupled receptor pathway. The hydrophobic and hydrophilic properties of the cellular membrane allows for the peptide and other hydrophilic hormones to bind to the receptor on the cellular surface but to not enter the cell. This regulation allows for activation despite the hormone’s short half-life. On the other hand, hydrophobic hormones must have longer half-lives to allow for these ligands to cross the lipid bilayer, travel through the cell’s cytosol and eventually reach the nucleus.

Cholesterol allows the lipid bilayer to maintain its fluidity despite the fluctuation in the body’s temperature due to events such as increasing metabolism. Cholesterol binds to the hydrophobic tails of the lipid bilayer. When the temperature is low, the cholesterol molecules prevent the hydrophobic tails from compacting and solidifying. When the temperature is high, the hydrophobic tails will be excited and will move excessively. This excess movement will bring instability to the bilayer. Cholesterol will prevent excessive movement.

Based on the passage, cholesterol has which of the following properties?

I. Hydrophilic

II. Hydrophobic

III. Can cross the lipid bilayer

Possible Answers:

III only

I only

二只

I, II, and III

II and III

Correct answer:

II and III

Explanation:

According to the passage, cholesterol interacts with the hydrophobic region of the lipid bilayer. Therefore, cholesterol must by hydrophobic. As mentioned in the passage that hydrophobic molecules are able to cross the bilayer.

Example Question #11 :Other Properties Of Biological Compounds

The cellular membrane is a very important structure. The lipid bilayer is both hydrophilic and hydrophobic. The hydrophilic layer faces the extracellular fluid and the cytosol of the cell. The hydrophobic portion of the lipid bilayer stays in between the hydrophobic regions like a sandwich. This bilayer separation allows for communication, protection, and homeostasis.

One of the most utilized signaling transduction pathways is the G protein-coupled receptor pathway. The hydrophobic and hydrophilic properties of the cellular membrane allows for the peptide and other hydrophilic hormones to bind to the receptor on the cellular surface but to not enter the cell. This regulation allows for activation despite the hormone’s short half-life. On the other hand, hydrophobic hormones must have longer half-lives to allow for these ligands to cross the lipid bilayer, travel through the cell’s cytosol and eventually reach the nucleus.

Cholesterol allows the lipid bilayer to maintain its fluidity despite the fluctuation in the body’s temperature due to events such as increasing metabolism. Cholesterol binds to the hydrophobic tails of the lipid bilayer. When the temperature is low, the cholesterol molecules prevent the hydrophobic tails from compacting and solidifying. When the temperature is high, the hydrophobic tails will be excited and will move excessively. This excess movement will bring instability to the bilayer. Cholesterol will prevent excessive movement.

Which of the following hormones utilizes cholesterol as a precursor?

I. Cortisol

II. Aldosterone

III. Epinephrine

Possible Answers:

I, II, and III

I only

III only

二只

I and II

Correct answer:

I and II

Explanation:

Both cortisol and aldosterone are synthesized in the adrenal cortex with cholesterol as the precursor, since they are steroid hormones. Epinephrine's precursor is tyrosine and it is soluble in water, which tells us that it is not steroid-derived.

Example Question #1 :Functional Groups And Properties

Shown above is the chemical structure for penicillin. Which of the arrows is pointing to an amide group?

Possible Answers:

C

B

D

A

Correct answer:

B

Explanation:

The correct answer is arrow B. An amide group is a carbonyl group with a nitrogen that is in the alpha position (directly attached to the carbonyl carbon). Penicillin has two different amide groups in its chemical structure, but only one has an arrow pointing to it in the diagram. Arrow B points to a primary secondary amide, bond to one hydrogen and two carbons. The other amide in the molecule is a tertiary amide, bond to three carbons and no hydrogens.

Penicillin_a

Example Question #2 :Functional Groups And Properties

Which of the following statements about amide bonds is NOT true?

Possible Answers:

Amide bonds are polar

The nitrogen ishybridized, while the carbon and oxygen arehybridized

Amides are formed by the combination of a carboxylic acid and an amine, resulting in the loss of water

Amides are mildly acidic, with primary amides having a pKaof approximately fifteen

A secondary amide has the following structure.

Mcat_8

Correct answer:

The nitrogen ishybridized, while the carbon and oxygen arehybridized

Explanation:

Amides have a structure of a ketone group adjacent to an amine group.

In an amide bond, all of the atoms (the nitrogen, the carbonyl oxygen, and carbonyl carbon) arehybridized because of resonance; the lone pair on nitrogen can delocalize into the carbonyl pi bond. The amide bond is polar, mildly acidic, with a secondary amide having the structure shown. Finally, amides are often formed by a condensation reaction between a carboxylic acid and an amine, which produces water as a byproduct.

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