Which of the following is not part of the adaptive immune response?

Which of the following correctly matches the type of immunity to the way it was recieved?

In the crusade to create a vaccine forPoliomyelitis, Jonas Salk and Albert Sabin created two separate vaccines that proved to be successful in preventing Polio onset.

The Salk vaccine, which is given by standard injection, contained virus particles inactivated by an organic solvent. This method has the advantage of inactivating each of the three Polio strains with no bias.

Albert Sabin's vaccine, given by oral inoculation via sugar water, contained live virus particles that had been genetically attenuated. With this method, each of the three Polio strains acquired separate mutations that made them unable to infect the human host cells. Strain 2 in particular contained one single nucleotide polymorphism in the internal ribosomal entry site (IRES) that prevented successful viral replication.

What type of immune response does inoculation with either vaccine stimulate?

Duchenne Muscular Dystrophy is an X-linked recessive genetic disorder, resulting in the loss of the dystrophin protein. In healthy muscle, dystrophin localizes to the sarcolemma and helps anchor the muscle fiber to the basal lamina. The loss of this protein results in progressive muscle weakness, and eventually death.

In the muscle fibers, the effects of the disease can be exacerbated by auto-immune interference. Weakness of the sarcolemma leads to damage and tears in the membrane. The body’s immune system recognizes the damage and attempts to repair it. However, since the damage exists as a chronic condition, leukocytes begin to present the damaged protein fragments as antigens, stimulating a targeted attack on the damaged parts of the muscle fiber. The attack causes inflammation, fibrosis, and necrosis, further weakening the muscle.

Studies have shown that despite the severe pathology of the muscle fibers, the innervation of the muscle is unaffected.

What is the best characterization of the immune response described in the passage?

Inflammation is an important response of the immune system. The vasodilation of blood vessels allows for important cells of the innate immune system to move out of the blood and into the surrounding tissue. Which of the following members of the innate immune system is responsible for causing inflammation at the site of infection?

The HIV virus infects which of the following cells in order to diminish coordinated immune responses against pathogens?

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the loss of tolerance to self antigens leading to the presence of high autoantibody titers. Dysregulated peripheral tolerance and hyperactive germinal centers have been proposed to be one of the driving forces behind the accumulation of high autoantibodies.

What immune cell type is the product of germinal centers and most likely the cell mediating the production of autoantibodies?

Which of the following is an example of a primary lymphoid organ?

Hypersensitivity reactions occur when body tissues are affected by an abnormal immune reaction. The result is damage to normal tissues and clinical illness. A peanut allergy is an example of a hypersensitivity reaction, but there are three additional broad classes.

One class involves the abnormal production or deposition of antibodies. Antibodies are B-cell derived molecules that normally adhere to pathogens, rendering them unable to continue an infection. When antibodies are produced against normal tissues, however, disease can result. Figure 1 depicts a schematic structure of an antibody.

Antibodies can be divided into two peptide chains: heavy and light. Heavy chains form the backbone of the antibody, and are attached to light chains via covalent bonding. Each heavy and light chain is then further divided into constant and variable regions. Variable regions exhibit molecular variety, generating a unique chemical identity for each antibody. These unique patterns help guarantee that the body can produce antibodies to recognize many possible molecular patterns on invading pathogens.

Unlike B-cells, T-cells do not make antibodies. T-cells are important in the execution of cytotoxic immunity, such as neutralizing virus-infected cells. A scientist is studying the T-cell response in a mammal, and finds that his CD8⁺T-cells are interacting with a surface protein found on many different types of cells in his model organism. This protein is most likely__________.

Which of the following combinations might yield the necessity of blood transfusion for a new born baby?