This passage is adapted from Adam K. Fetterman and Kai Sassenberg, “The Reputational Consequences of Failed Replications and Wrongness Admission among Scientists", first published in December 2015 by PLOS ONE.

我们喜欢把科学当作一个纯粹的理性。However, scientists are human and often identify with their work. Therefore, it should not be controversial to suggest that emotions are involved in replication discussions. Adding to this inherently emotionally volatile situation, the recent increase in the use of social media and blogs by scientists has allowed for instantaneous, unfiltered, and at times emotion-based commentary on research. Certainly social media has the potential to lead to many positive outcomes in science–among others, to create a more open science. To some, however, it seems as if this ease of communication is also leading to the public tar and feathering of scientists. Whether these assertions are true is up for debate, but we assume they are a part of many scientists’ subjective reality. Indeed, when failed replications are discussed in the same paragraphs as questionable research practices, or even fraud, it is hard to separate the science from the scientist. Questionable research practices and fraud are not about the science; they are about the scientist. We believe that these considerations are at least part of the reason that we find the overestimation effect that we do, here.

Even so, the current data suggests that while many are worried about how a failed replication would affect their reputation, it is probably not as bad as they think. Of course, the current data cannot provide evidence that there are no negative effects; just that the negative impact is overestimated. That said, everyone wants to be seen as competent and honest, but failed replications are a part of science. In fact, they are how science moves forward!

While we imply that these effects may be exacerbated by social media, the data cannot directly speak to this. However, anyone of a number of cognitive biases may add support to this assumption and explain our findings. For example, it may be that a type of availability bias or pluralistic ignorance of which the more vocal and critical voices are leading individuals to judge current opinions as more negative than reality. As a result, it is easy to conflate discussions about direct replications with “witch- hunts” and overestimate the impact on one’s own reputation. Whatever the source may be, it is worth looking at the potential negative impact of social media in scientific conversations.

如果欲望是推动科学,scientists need to be able to acknowledge when they are wrong. Theories come and go, and scientists learn from their mistakes (if they can even be called “mistakes”). This is the point of science. However, holding on to faulty ideas flies in the face of the scientific method. Even so, it often seems as if scientists have a hard time admitting wrongness. This seems doubly true when someone else fails to replicate a scientist’s findings. Even so, it often seems as if scientists have a hard time admitting wrongness. This seems doubly true when someone else fails to replicate a scientist’s findings. In some cases, this may be the proper response. Just as often, though, it is not. In most cases, admitting wrongness will have relatively fewer ill effects on one’s reputation than not admitting and it may be better for reputation. It could also be that wrongness admission repairs damage to reputation.

It may seem strange that others consider it less likely that questionable research practices, for example, were used when a scientist admits that they were wrong. However, it does make sense from the standpoint that wrongness admission seems to indicate honesty. Therefore, if one is honest in one domain, they are likely honest in other domains. Moreover, the refusal to admit might indicate to others that the original scientist is trying to cover something up. The lack of significance of most of the interactions in our study suggests that it even seems as if scientists might already realize this. Therefore, we can generally suggest that scientists admit they are wrong, but only when the evidence suggests they should.

The chart below maps how scientists view others' work (left) and how they suspect others will view their own work (right) if the researcher (the scientist or another, depending on the focus) admitted to engaging in questionable research practices.

Adapted from Fetterman & Sassenberg, "The Reputational Consequences of Failed Replications and Wrongness Admission among Scientists." December 9, 2015, PLOS One.

This passage is adapted from Jane Austen, Mansfield Park. Originally published 1814. Fanny has recently moved to live with her relatives at Mansfield Park.

The little girl performed her long journey in safety; and at Northampton was met by Mrs. Norris, who thus regaled in the credit of being foremost to welcome her, and in the importance of leading her in to the others, and recommending her to their kindness.

Fanny Price was at this time just ten years old, and though there might not be much in her first appearance to captivate, there was, at least, nothing to disgust her relations. She was small of her age, with no glow of complexion, nor any other striking beauty; exceedingly timid and shy, and shrinking from notice; but her air, though awkward, was not vulgar, her voice was sweet, and when she spoke her countenance was pretty. Sir Thomas and Lady Bertram received her very kindly; and Sir Thomas, seeing how much she needed encouragement, tried to be all that was conciliating: but he had to work against a most untoward gravity of deportment; and Lady Bertram, without taking half so much trouble, or speaking one word where he spoke ten, by the mere aid of a good-humored smile, became immediately the less awful character of the two.

The young people were all at home, and sustained their share in the introduction very well, with much good humor, and no embarrassment, at least on the part of the sons, who, at seventeen and sixteen, and tall of their age, had all the grandeur of men in the eyes of their little cousin. The two girls were more at a loss from being younger and in greater awe of their father, who addressed them on the occasion with rather an injudicious particularity. But they were too much used to company and praise to have anything like natural shyness; and their confidence increasing from their cousin's total want of it, they were soon able to take a full survey of her face and her frock in easy indifference.

他们是一个非常好的家庭,儿子非常well-looking, the daughters decidedly handsome, and all of them well-grown and forward of their age, which produced as striking a difference between the cousins in person, as education had given to their address; and no one would have supposed the girls so nearly of an age as they really were. There were in fact but two years between the youngest and Fanny. Julia Bertram was only twelve, and Maria but a year older.

The little visitor meanwhile was as unhappy as possible. Afraid of everybody, ashamed of herself, and longing for the home she had left, she knew not how to look up, and could scarcely speak to be heard, or without crying. Mrs. Norris had been talking to her the whole way from Northampton of Fanny’s wonderful good fortune, and the extraordinary degree of gratitude and good behavior which it ought to produce, and her consciousness of misery was therefore increased by the idea of its being a wicked thing for her not to be happy.

The fatigue, too, of so long a journey, became soon no trifling evil. In vain were the well-meant condescensions of Sir Thomas, and all the officious prognostications of Mrs. Norris that she would be a good girl; in vain did Lady Bertram smile and make her sit on the sofa with herself and pug, and vain was even the sight of a gooseberry tart towards giving her comfort; she could scarcely swallow two mouthfuls before tears interrupted her, and sleep seeming to be her likeliest friend, she was taken to finish her sorrows in bed.

“This is not a very promising beginning,” said Mrs. Norris, when Fanny had left the room.“After all that I said to her as we came along, I thought she would have behaved better; I told her how much might depend upon her acquitting herself well at first. I wish there may not be a little sulkiness of temper—her poor mother had a good deal; but we must make allowances for such a child—and I do not know that her being sorry to leave her home is really against her, for, with all its faults, it was her home, and she cannot as yet understand how much she has changed for the better; but then there is moderation in all things.”

It required a longer time, however, than Mrs. Norris was inclined to allow to reconcile Fanny to the novelty of Mansfield Park, and the separation from everybody she had been used to. Her feelings were very acute and too little understood to be properly attended to. Nobody meant to be unkind, but nobody put themselves out of their way to secure her comfort.

Fanny, whether near or from her cousins, whether in the schoolroom, the drawing-room, or the shrubbery, was equally forlorn, finding something to fear in every person and place. She was disheartened by Lady Bertram's silence, awed by Sir Thomas's grave looks, and quite overcome by Mrs. Norris's admonitions. Her elder cousins mortified her by reflections on her size, and abashed her by noticing her shyness: Miss Lee wondered at her ignorance, and the maid-servants sneered at her clothes; and when to these sorrows was added the idea of the brothers and sisters among whom she had always been important as playfellow, instructress, and nurse, the despondence that sunk her little heart was severe.

In the context of the passage, Mrs. Norris's statement in the highlighted lines serves to

This passage is adapted from Jane Austen, Mansfield Park. Originally published 1814. Fanny has recently moved to live with her relatives at Mansfield Park.

The little girl performed her long journey in safety; and at Northampton was met by Mrs. Norris, who thus regaled in the credit of being foremost to welcome her, and in the importance of leading her in to the others, and recommending her to their kindness.

Fanny Price was at this time just ten years old, and though there might not be much in her first appearance to captivate, there was, at least, nothing to disgust her relations. She was small of her age, with no glow of complexion, nor any other striking beauty; exceedingly timid and shy, and shrinking from notice; but her air, though awkward, was not vulgar, her voice was sweet, and when she spoke her countenance was pretty. Sir Thomas and Lady Bertram received her very kindly; and Sir Thomas, seeing how much she needed encouragement, tried to be all that was conciliating: but he had to work against a most untoward gravity of deportment; and Lady Bertram, without taking half so much trouble, or speaking one word where he spoke ten, by the mere aid of a good-humored smile, became immediately the less awful character of the two.

The young people were all at home, and sustained their share in the introduction very well, with much good humor, and no embarrassment, at least on the part of the sons, who, at seventeen and sixteen, and tall of their age, had all the grandeur of men in the eyes of their little cousin. The two girls were more at a loss from being younger and in greater awe of their father, who addressed them on the occasion with rather an injudicious particularity. But they were too much used to company and praise to have anything like natural shyness; and their confidence increasing from their cousin's total want of it, they were soon able to take a full survey of her face and her frock in easy indifference.

他们是一个非常好的家庭,儿子非常well-looking, the daughters decidedly handsome, and all of them well-grown and forward of their age, which produced as striking a difference between the cousins in person, as education had given to their address; and no one would have supposed the girls so nearly of an age as they really were. There were in fact but two years between the youngest and Fanny. Julia Bertram was only twelve, and Maria but a year older.

The little visitor meanwhile was as unhappy as possible. Afraid of everybody, ashamed of herself, and longing for the home she had left, she knew not how to look up, and could scarcely speak to be heard, or without crying. Mrs. Norris had been talking to her the whole way from Northampton of Fanny’s wonderful good fortune, and the extraordinary degree of gratitude and good behavior which it ought to produce, and her consciousness of misery was therefore increased by the idea of its being a wicked thing for her not to be happy.

The fatigue, too, of so long a journey, became soon no trifling evil. In vain were the well-meant condescensions of Sir Thomas, and all the officious prognostications of Mrs. Norris that she would be a good girl; in vain did Lady Bertram smile and make her sit on the sofa with herself and pug, and vain was even the sight of a gooseberry tart towards giving her comfort; she could scarcely swallow two mouthfuls before tears interrupted her, and sleep seeming to be her likeliest friend, she was taken to finish her sorrows in bed.

“This is not a very promising beginning,” said Mrs. Norris, when Fanny had left the room. “After all that I said to her as we came along, I thought she would have behaved better; I told her how much might depend upon her acquitting herself well at first. I wish there may not be a little sulkiness of temper—her poor mother had a good deal; but we must make allowances for such a child—and I do not know that her being sorry to leave her home is really against her, for, with all its faults, it was her home, and she cannot as yet understand how much she has changed for the better; but then there is moderation in all things.”

It required a longer time, however, than Mrs. Norris was inclined to allow to reconcile Fanny to the novelty of Mansfield Park, and the separation from everybody she had been used to. Her feelings were very acute and too little understood to be properly attended to. Nobody meant to be unkind, but nobody put themselves out of their way to secure her comfort.

Fanny, whether near or from her cousins, whether in the schoolroom, the drawing-room, or the shrubbery, was equally forlorn, finding something to fear in every person and place. She was disheartened by Lady Bertram's silence, awed by Sir Thomas's grave looks, and quite overcome by Mrs. Norris's admonitions. Her elder cousins mortified her by reflections on her size, and abashed her by noticing her shyness: Miss Lee wondered at her ignorance, and the maid-servants sneered at her clothes; and when to these sorrows was added the idea of the brothers and sisters among whom she had always been important as playfellow, instructress, and nurse, the despondence that sunk her little heart was severe.

The main purpose of the highlighted paragraph is to

Passage 2 is adapted from Benjamin Rush, "Thoughts upon Female Education". Originally published 1787.

A philosopher once said, "let me make all the ballads of a country and I care not who makes its laws." He might with more propriety have said, let the ladies of a country be educated properly, and they will not only make and administer its laws, but form its manners and character. It would require a lively imagination to describe, or even to comprehend, the happiness of a country where knowledge and virtue were generally diffused among the female sex. Our young men would then be restrained from vice by the terror of being banished from their company. The loud laugh and the malignant smile, at the expense of innocence or of personal infirmities– the feats of successful mimicry and the low priced wit which is borrowed from a misapplication of scripture phrases– would no more be considered as recommendations to the society of the ladies. A double-entendre in their presence would then exclude a gentleman forever from the company of both sexes and probably oblige him to seek an asylum from contempt in a foreign country.

If I am wrong in those opinions in which I have taken the liberty of departing from the general and fashionable habits of thinking I am sure you will discover and pardon my mistakes.But if I am right, I am equally sure you will adopt my opinions for to enlightened minds truth is alike acceptable, whether it comes from the lips of age or the hand of antiquity or whether it be obtruded by a person who has no other claim to attention than a desire of adding to the stock of human happiness.

你,年轻的女士,一个重要的问题是通讯itted for solution: whether our present plan of education be a wise one and whether it be calculated to prepare you for the duties of social and domestic life. I know that the elevation of the female mind, by means of moral, physical, and religious truth, is considered by some men as unfriendly to the domestic character of a woman. But this is the prejudice of little minds and springs from the same spirit which opposes the general diffusion of knowledge among the citizens of our republics.If men believe that ignorance is favorable to the government of the female sex, they are certainly deceived, for a weak and ignorant woman will always be governed with the greatest difficulty. It will be in your power ladies, to correct the mistakes and practice of our sex upon these subjects by demonstrating that the female temper can only be governed by reason and that the cultivation of reason in women is alike friendly to the order of nature and to private as well as public happiness.

第二段的第一句话the passage is primarily intended as

The following passage is adapted from Ricki Lewis, "Did Donkeys Arise from an Inverted Chromosome?", originally published 2018 in PLOSOne Blogs.

In the world of genome sequencing, donkeys haven’t received nearly as much attention as horses. But now a report on a new-and-improved genome sequence of Willy, a donkey (Equus asinus) jack 5 born at the Copenhagen Zoo in 1997, appears in the new issue of Science Advances, from Gabriel Renaud, of the Centre for GeoGenetics, Natural History Museum of Denmark. (A female is a jenny or jennet.) The new view provides clues to how donkeys may have branched from horses along the tree of evolution.

Horses and their relatives, past and present, are genetically peculiar in that their chromosomes are rearranged, with respect to each other. That should prevent them from producing viable hybrids – yet they do. Donkeys have 62 chromosomes and horses have 64. A mule comes from the mating of a male donkey and a female horse, and has 63 chromosomes. Mules are known for their intelligence, calm, stamina, and persistence. Their horse-like bodies perched on donkey-like limbs make them ideal for hauling tourists around the Grand Canyon and schlepping supplies in combat situations. The ears are large like those of the horse mom, and mules make a sound that begins as a whinny and becomes a bray.

The complementary couple, a female donkey and a male horse, produces a hinny, smaller than a mule. Hinnies are the flip side of the mule, with a donkey’s physique atop horsey limbs, and short donkey ears. They’re rarer than mules, but also have 63 chromosomes. It’s easy to mix them up.

Comparing Willy’s genome to a horse genome revealed their close evolutionary relationship. Only about 15% of horse genes aren’t also in the donkey genome, and only about 10% of a donkey’s genes don’t have counterparts in the horse. Most of the genes that they share provide basic “housekeeping” functions like dismantling proteins, repairing DNA, enabling embryonic development, and controlling cell division. So that’s why a copy of each genome can smush together to yield mules and hinnies.

第二种形式的信息编码在基因组,我n addition to the A, C, T, G sequence, is the pattern of whether the two variants of individual genes are different (heterozygous) or the same (homozygous). Many contiguous homozygous genes form a “run of homozygosity” (ROH).

An ROH indicates a chromosome chunk, perhaps as long as millions of DNA bases, that’s the same from each of an individual’s parents, who in turn inherited it from a shared ancestor, like a grandparent that cousins share. The longer the ROH, the more recent the shared ancestor, because it takes time for mutations to accrue that would break the sameness of the sequence.

Scrutinizing ROHs can reveal recent inbreeding and domestication, help to reconstruct possible branching patterns of evolution, and, more practically, help ancestry companies assign the DNA inspit samplesto geographic areas where people’s ancestors might have come from.The new study compared ROHs for the three zebra and three ass species, confirming that Willy’s most recent ancestors were Somali wild asses.

The researchers used Chicago HiRise assembly technology to up the quality of Willy’s genome sequence. “This new assembly allowed us to identify fine chromosomal rearrangements between the horse and the donkey that likely played an active role in their divergence and, ultimately, speciation,” they write.

The bigger pieces enabled them to zero in on DNA sequences where chromosomes contort, such as inversions (where a sequence flips) or translocations (where different chromosome types exchange parts). These events could have fueled the reproductive isolation of small populations that can expand into speciation.

If eventually sperm with one inverted chromosome fertilized eggs with the same inversion, animals would have been conceived in which both copies of the chromosome are inverted – and they’d be fertile with each other, but not with horses. Once a subpopulation with the inversion became established, further genetic changes would separate them further from the ancestral horse.